Molecular structure of a heart attack

New research by Dr Carmine Gentile and his team has helped observe and understand how the molecules change following a heart attack. This world first research has helped identify which molecules change following a heart attack, giving them new approaches to investigate how to prevent and treat the irreversible damages caused by a heart attack which currently, is irreversible.

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Heart attack awareness for over 35s vital

Heart attack awareness for over-35s vital to mitigating serious cardiac risk during exercise Professor Geoffrey Tofler and his team have just published a new study assessing the knowledge and confidence in recognising cardiac symptoms amongst players of competitive to social football games. This latest research found that almost half of over-35s were not confident in

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A World-First Surgical Instrument for Minimally Invasive Robotically-Enabled Transplantation of Heart Patches for Myocardial Regeneration:

Dr Chris Roche, a cardiac surgical trainee funded by HROz since 2019, has brought surgical skills and insights to the research team supervised by Dr Carmine Gentile – a bioprinting expert working towards producing heart patches made of special ‘bio-ink’. Dr Roche has been working on a spin-off project to his PhD where he has designed and prototyped

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The SWEDEHEART Project

The SWEDEHEART study found SMuRF-less patients have higher in-hospital mortality compared with traditional high-risk individuals. This is particularly evident in women.

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Long Term Cardiac Implications in Pre-term Babies

A new study in the Department of Neonatology at Royal North Shore Hospital tracks the development of small blood vessels and blood pressure of premature babies. Over the next three years, approximately 80 preterm and term babies will be followed from birth at different weeks of gestation until age 1. New techniques of ultrasound imaging will be used to trace the blood vessels in the kidneys and aorta, as well as new measurements of blood pressure and kidney function. We hope insights from this study shed light onto the cardiovascular consequences of premature birth. Ultimately, increased knowledge of the contributing factors toward hypertension will help identify the highest risk groups and allow early intervention to prevent later heart disease.

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Growing new arteries – an alternative for stent or bypass surgery.

Dr Allahwala found through pilot studies that some patients with a CTO can develop and mature new arteries, called collaterals. These collaterals supply the heart muscle with blood and oxygen, thereby preventing a heart attack. The reasons and mechanisms why some people can develop new arteries and others can’t is unclear. The effect collaterals have on blood pressure and flow within the coronary vessels is also unknown. 

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Smoking Cessation Through Personal Identification

Professor Tofler has been working on a novel approach to smoking cessation, supported by a grant from Heart Research Australia and SPARK innovation award. This work uses video to create a simulated teachable moment and builds on the clinical observation that many smokers can stop smoking once they have experienced a heart attack. The goal

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Research To Prevent Cardiac Side Effects From Breast Cancer Treatment 

Lead Researchers: Prof Helge Rasmussen, Dr Chia-Chi Liu, Elisha Hamilton Professor Helge Rasmussen and his team are working on a way to help breast cancer survivors reduce their risk of irreversible heart damage. Heart Research Australia is delighted to share the news that thanks to an anonymous benefactor, combined with Heart Research Australia donors, we

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Lab Manager

Dr Hamilton is directly responsible for performing many of the experiments that are conducted within Prof Rasmussen’s laboratory as well as providing a supervisory role to both students and research assistants within the lab. Her role as Laboratory Manager requires that she balances the scientific needs of the staff within the Rasmussen laboratory, with the

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Oxidative Signaling

Professor Figtree’s Laboratory strives to understand the way reactive oxygen species affect disease in the heart and blood vessels. Professor Figtree and her team have identified a novel protein that plays a pivotal role in protecting the cardiovascular system from these oxidative stresses and loss of this protein exacerbates disease progression. They are now dissecting

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FXYD – An Endogenous Protector of the Vasculature

Cardiovascular disease is a major cause of morbidity and mortality in Australia. Dr Hanson is a medical doctor embarking on a PhD in basic and translational cardiovascular research. With an overall aim of improving the identification and treatment of patients with cardiovascular disease, his PhD project encompasses two interrelated themes. Circulating biomarkers of oxidative stress

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Can we use MRI to identify arteries at most risk from plaque formation?

Lead Researcher: Dr Paul Bonnitcha Hardening of the arteries and the formation of fatty plaques lining them are major contributors to strokes, heart attacks and peripheral vascular disease. Currently there is no way of knowing which plaques are most likely to rupture and cause problems. Recent findings indicate that plaque instability may be related to

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APTS (Australian Placental Transfusion Study)

Lead Researcher: Prof Martin Kluckow The first results of this trial were published in the New England Journal of Medicine showing that delayed cord clamping can reduce mortality in preterm infants and is safe to apply. The follow up of the trial is ongoing and Professor Kluckow and his team will continue to track these

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The u-PDA Trial (Ultimate PDA Trial)

Lead Researcher: Prof Martin Kluckow This is a pilot randomized control trial (RCT) of active medical treatment vs supportive care alone of the patent ductus arteriosus (PDA) in babies born before 28 weeks of pregnancy. This placebo controlled clinical trial was the first time targeted early treatment of the patent ductus arteriosus (PDA) was utilised

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Is pre-eclampsia in pregnancy related to pregnancy induced heart failure?

Lead Researcher:  Dr Anthony Ashton Most pregnancies end with the birth of a healthy baby to a healthy mother; however, some pregnancies end in unforeseen and currently untreatable complications. Unfortunately, the signs that something is wrong in these pregnancies appear to be “normal” for most women at the end of pregnancy.  Headaches, swelling and difficulty

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Discovery of new mechanisms for coronary disease

Lead Researcher: Professor Gemma Figtree  Cardiovascular disease remains the leading cause of death in Australia and has enormous social and economic impact across the globe. Despite common perceptions, it is not all solved. Despite major advances in the understanding and treatment of heart disease, there remains a large gap in our knowledge of what drives

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A novel combination for heart failure

Lead Researchers: Prof Helge Rasmussen, Dr Chia-Chi Liu, Dr Elisha Hamilton Heart failure is the leading cause of disability and death in the world. While many drugs are used in treatment, this innovative research has discovered that a new group of drugs, β3-AR agonists (one of which is already used as a treatment for an

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Prevention of cardiac side effects of cancer treatment

Lead Researchers: Prof Helge Rasmussen, Dr Chia-Chi Liu Heart muscle damage and heart failure is a serious side effect of cancer treatments and it is not uncommon that the life expectancy of cancer patients is limited due to heart disease induced by the cancer treatment, rather than by the cancer itself. While very effective against

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The Triggered Acute Risk Prevention Study

Lead Researchers: Prof Geoff Tofler and A/Prof Thomas Buckley Increasing evidence shows that heart attacks in some instances can be triggered by external factors such as heavy physical exertion, acute emotional stress, heavy fatty meals, and respiratory infection.  For instance, the group published findings that respiratory infection acutely increases the relative risk of heart attack

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