There is evidence that some heart attacks can be abruptly triggered by certain stressors. Cardiologist Geoffrey Tofler heads a team that is researching ways to use this knowledge and save lives.
Much research has been done on long-term risk factors for heart disease, such as cholesterol and hypertension. But there is less understanding of short-term changes that occur just before a heart attack.
The research team (from left): Monica Spinaze (RN), Dr Elizabeth Shaw, Professor Geoffrey Tofler, Dr Tom Buckley.
This area of enquiry has been a long-standing interest of preventative cardiologist Geoffrey Tofler. His study of immediate risk factors is known as TARP (Triggered Acute Risk Prevention).
Prevention with a single dose
The project investigates the feasibility of using a single dose of medication when there is an increased risk from certain triggers, in particular:
- heavy physical exertion
- severe emotional stress
- a heavy meal
- respiratory infection
Medication includes familiar treatments such as aspirin and beta-blockers (common heart drugs).
Seventeen healthy volunteers enrolled in the first phase of the study (known as TARP I). After careful instruction, they took specific medication just before or at the time of an acute triggering activity.
Results
Preliminary results show that the volunteers reliably documented triggers and took their medication. Findings included reduced heart rate during physical exertion, compared to when not taking the therapy.
Over two-thirds said it was feasible to continue taking medication in this way.
The results show that:
- potential triggers of acute cardiovascular disease can be reliably identified
- it is feasible and acceptable to take targeted medication at the time of these triggers.
